While the full 2021 NFL schedule won't be out until later in the day, the NFL did announce its Week 1 schedule on Wednesday morning, and the Seahawks will kick off their 2021 regular season with a trip to Indianapolis.
The Seahawks' opener against the Colts is on Sunday, September 12 and will kick off at 10 a.m. PT on FOX.
The full schedule will be released at 5 p.m., and you can find all the info on Seahawks.com and Seahawks social media channels. There is also a schedule release show on the NFL Network starting at 5 p.m. For local fans, Q13 FOX will be live at 5 p.m. PT with a game-by-game breakdown of the schedule and analysis from sports director Aaron Levine and Seahawks Legend Michael Bumpus.
The trip to Indy will be the first for Seattle since 2013, a game the Seahawks lost 34-28, one of only three losses in that Super Bowl-winning season. The two teams last faced off in 2017 with the Seahawks winning 46-18 behind three Russell Wilson touchdowns and two defensive scores. The Colts should be a tough opening test for Seattle, having gone 11-5 last year to make the playoffs for the second time in three seasons under head coach Frank Reich. The Colts will have a new quarterback this year, having traded for former Eagles starter Carson Wentz following the retirement of Philip Rivers.
While in the past a 10 a.m. PT kickoff was seen as a significant disadvantage for the Seahawks, they've handled those games well in recent years despite the early wakeup call. The Seahawks went 3-1 in that time slot last year, including a season-opening win in Atlanta, and were 5-0 in early games in 2019. Dating back to 2013, the Seahawks are 19-7 in games that kick off at 10 a.m. PT.
A look at the teams the Seattle Seahawks will face during the 2021 regular season. The schedule will be released on May 12. Sign up to be notified when the schedule is out, as well as when single game tickets are available for purchase: https://shwks.com/ekrwsh

Pittsburgh Steelers wide receiver JuJu Smith-Schuster (19) runs after catch during the second half of an NFL football game against the Indianapolis Colts, Sunday, Dec. 27, 2020, in Pittsburgh. (AP Photo/Gene J. Puskar)

Los Angeles Rams cornerback Jalen Ramsey (20) defends in coverage on defense during an NFL wild-card playoff football game against the Seattle Seahawks, Saturday, Jan. 9, 2021, in Seattle. The Rams defeated the Seahawks, 30-20. (Ryan Kang via AP)

Minnesota Vikings wide receiver Justin Jefferson (18) reaches for the ball during the first half of an NFL football game against the Chicago Bears, Sunday, Dec. 20, 2020 in Minneapolis. The Bears defeated the Vikings 33-27. (Alika Jenner via AP)

San Francisco 49ers tight end George Kittle (85) celebrates as he runs the football to score a touchdown during an NFL football game against the Los Angeles Rams, Sunday, Oct. 18, 2020, in Santa Clara, Calif. The 49ers defeated the Rams, 24-16. (Ryan Kang via AP)

Arizona Cardinals quarterback Kyler Murray (1) throws the ball during an NFL football game against the Los Angeles Rams, Sunday, Jan. 3, 2021 in Inglewood, Calif. (Ben Liebenberg via AP)

Los Angeles Rams defensive tackle Aaron Donald (99), left, sprints towards New England Patriots quarterback Cam Newton (1), not shown, past New England Patriots offensive tackle Justin Herron (75) during an NFL football game Thursday, Dec. 10, 2020, in Inglewood, Calif. (AP Photo/Kyusung Gong)

San Francisco 49ers defensive end Nick Bosa (97) in action against the New York Jets during an NFL football game, Sunday, Sept. 20, 2020, in East Rutherford, N.J. (AP Photo/Adam Hunger)

Tennessee Titans running back Derrick Henry (22) runs the ball during an NFL game against the Houston Texans, Sunday, Jan. 03, 2021, in Houston. (Cooper Neill via AP)

Arizona Cardinals wide receiver DeAndre Hopkins (10) scores a touchdown as Philadelphia Eagles defensive back Michael Jacquet (38) defends during the second half of an NFL football game, Sunday, Dec. 20, 2020, in Glendale, Ariz. (AP Photo/Rick Scuteri)

Chicago Bears outside linebacker Khalil Mack (52) runs around the edge during an NFL wild-card playoff football game against the New Orleans Saints, Sunday, Jan. 10, 2021, in New Orleans. The Saints beat the Bears 21-9. (Peter Read Miller via AP)

Washington Football Team defensive end Chase Young (99) in action during an NFL football game against the Los Angeles Rams, Sunday, Oct. 11, 2020 in Landover, Md. (AP Photo/Daniel Kucin Jr.)

Detroit Lions cornerback Justin Coleman (27) waits on the play during the first half of an NFL football game against the Dallas Cowboys, Sunday, Nov. 17, 2019, in Detroit. (AP Photo/Paul Sancya)

Jacksonville Jaguars outside linebacker Myles Jack (44) readies for the play in the second quarter during an NFL football game against the Minnesota Vikings, Sunday, Dec. 6, 2020, in Minneapolis. The Vikings defeated the Jaguars 27-24. (AP Photo/David Berding)

New Orleans Saints running back Alvin Kamara (41) in the fourth quarter against the Minnesota Vikings in an NFL game, Friday, December 25, 2020 in New Orleans, LA. (Michael DeMocker via AP)

Green Bay Packers quarterback Aaron Rodgers (12) drops back to pass during the NFC Championship game against the Tampa Bay Buccaneers, Saturday, January 24, 2021 in Green Bay, Wis. (Todd Rosenberg via AP)

Indianapolis Colts wide receiver T.Y. Hilton (13) catches a deep pass during an NFL football game against the Tennessee Titans on Sunday, Nov. 29, 2020, in Indianapolis. (AP Photo/Zach Bolinger)

Houston Texans running back David Johnson runs up field during the first half of an NFL football game against the Minnesota Vikings Sunday, Oct. 4, 2020, in Houston. (AP Photo/Eric Christian Smith)