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Picks And Predictions For Week 2 Matchup Against The San Francisco 49ers

Local and national media members make their picks for our Week 2 matchup against the 49ers.

picks-and-predictions sep 16

3 ESPN experts are picking the Seahawks to beat the 49ers this week in San Fransisco. ESPN's Laura Rutledge, Seth Wickersham, and Damien Woody were the 3/10 experts to choose the Seahawks over the 49ers in this weeks matchup.

CBS Sports NFL's Pete Prisco is picking the 49ers to win by a slight margin of 29-23 over the Seahawks for the Week 2 matchup in San Francisco. "Seattle played well in upsetting the Broncos on Monday night, but now they head out on a short week. That's a challenge. The 49ers didn't play well in the bad conditions at Soldier Field in losing to the Bears but that will change here. Trey Lance gets it going."

NBC Sports Pro Football Talk's Mike Florio is choosing the Seahawks to beat the 49ers in a close 20-17 game. "The Seahawks typically do well against the 49ers, and Trey Lance continues to be a huge question mark."

Adam Jude of The Seattle Times takes the Seahawks over the 49ers in a tight 23-20 game in Week 2. "The Seahawks' dominance of the Niners in the Bay Area continues, with Rashaad Penny and DK Metcalf busting out and Seattle's defense shutting down young Trey Lance."

Sam Farmer of The Los Angeles Times is choosing the 49ers to run away with a 31-17 win at home over the Seahawks. "Seahawks won their Super Bowl last week by sending Russell Wilson home in defeat. The 49ers were humiliated at Chicago and, behind their running game, should bounce back in home opener."

Scott Whittum of Athlon Sports takes the Seahawks to beat the 49ers 20-16 for their first away game of the season. "These two teams have historically played highly competitive games, as six of the last seven games have been decided by one score. The Seahawks are also 17-4 in their previous 21 games against the 49ers. They have not been blown out in San Francisco since a 33-17 loss on Sept. 11, 2011. The Seahawks will do just enough on offense to survive and advance to 2-0 in the young season."

The Seattle Seahawks take on the San Francisco for Week 2 of the 2022 season, the 48th meeting between the two teams. Take a look back at some of their previous matchups.

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