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Picks And Predictions For The Divisional Round vs. the San Francisco 49ers

The Seattle Seahawks face the 49ers on January 17 at Lumen Field as part of the divisional round of the NFL playoffs of the 2025 season. Kickoff is set for 5:00 p.m. PT. Here’s what local and national media are predicting:

Seahawks-vs-49ers-Picks-and-Predictions

The Seattle Seahawks (14-3) take on the San Francisco 49ers (12-5) for the divisional game at Lumen Field. Click here to learn how to watch, listen, and stream the action.

Bill Bender, Sporting News: Seahawks 24, 49ers 20

"It's the third matchup between the NFC West rivals. Seattle beat the 49ers 13-3 in Week 18 – a game that clinched home-field advantage. The Seahawks had 181 passing yards and 180 rushing yards in that game – a perfect balance of time management and efficient play from Sam Darnold. This is a huge game for Darnold, who is 28-6 as a starter in the regular season the last two years but 0-1 in the playoffs. He's averaged 174 passing yards with no TDs and no interceptions in the two matchups with the 49ers this season. San Francisco quarterback Brock Purdy is 5-2 in the playoffs and played through the mistakes – and losing tight end George Kittle – in the 23-19 victory at Philadelphia in the NFC Wild Card round. Purdy has taken two sacks or less in those seven playoff starts. The 49ers will lean on Christian McCaffrey – and the yards will be tough against the top rushing defense in the NFC. San Francisco also didn't have tackle Trent Williams in the Week 18 matchup. It's going to be a tighter matchup this time – and look for Seattle receiver Jaxon Smith-Njigba – who averaged 104 receiving yards in the two regular-season games – to make a few game-changing plays when it matters. Darnold gets his first playoff victory."

Vinnie Iyer, Sporting News: Seahawks 23, 49ers 20

"The 49ers overachieved with their injury-riddled defense in Philadelphia to advance to this rubber match in Seattle, as the 49ers won there in Week 1 and the Seahawks won in San Francisco in Week 18. The Seahawks are rested and ready, with their defense, running game and Sam Darnold set up to better produce in this game than the 49ers, now that Brock Purdy is without tight end George Kittle again.

The 49ers will dig deep with Christian McCaffrey and their wide receivers to stay competitive, but if the Seahawks protect the ball at home, they should take control of the game and outscore them."

Pete Prisco, CBS Sports: Seahawks 24, 49ers 20

"This is a real challenge for the 49ers with all the injuries they've had to deal with, the latest being losing tight end George Kittle. The Seahawks beat the 49ers in the regular-season finale to lock up the top seed. That game was won by their defense. But left tackle Trent Williams didn't play in that one for the 49ers. That matters. I think Brock Purdy will keep the 49ers in this one, but the Seahawks will find a way to pull it out to advance to the NFC Championship."

More Picks From Around The Web

Mike Florio, NBC Sports: 49ers 27, Seahawks 24

Chris Simms, NBC Sports: Seahawks 27, 49ers 17

Pamela Maldonado, ESPN: Seahawks 21, 49ers 10

Ben Solak, ESPN: Seahawks 20, 49ers 13

Seth Walder, ESPN: Seahawks 23, 49ers 20

Eric Moody, ESPN: Seahawks 30, 49ers 17

Ali Bhanpuri, NFL.com: Seahawks 24, 49ers 20

Brooke Cersosimo NFL.com: Seahawks 27, 49ers 23

Dan Parr, NFL.com: Seahawks 21, 49ers 13

Gennaro Filice, NFL.com: Seahawks 27, 49ers 17

Tom Blair, NFL.com: Seahawks 26, 49ers 20

Check out photos of the Seahawks 53-man active roster for the 2025 season.

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