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Picks And Predictions For Week 18 vs. the San Francisco 49ers

The Seattle Seahawks face the 49ers on January 3 at Levi’s Stadium as part of Week 18 of the 2025 season. Kickoff is set for 5:00 p.m. PT. Here’s what local and national media are predicting: 

Week-18-Seahawks-49ers-Picks-Predictions

The Seattle Seahawks (13-3) take on the San Francisco 49ers (12-4) for Week 18 at Levi's Stadium. Click here to learn how to watch, listen, and stream the action.

Bill Bender, Sporting News: 49ers 30, Seahawks 27

"This is for home-field advantage in the NFC. San Francisco averages 39 points per game since its Week 14 bye week – and Brock Purdy averages 297.7 passing yards with 11 TDs and two interceptions in that stretch. Sam Darnold will have success against an injury-plagued 49ers defense, too, which means this game could easily hit the over. This is a much different game than the 17-13 slugfest San Francisco won in Week 1."

Vinnie Iyer, Sporting News: 49ers 27, Seahawks 24

"The Seahawks are rolling with their formula of running game and defense lifting up Sam Darnold in the passing game. The 49ers, with their defensive injuries and sometimes run-blocking issues, have been more about opening up the offense with Brock Purdy to win games with plenty of dual-threat Christian McCaffrey. San Francisco has been inspired and scrappy for Kyle Shanahan and knows it can stay at home all the way through Super Bowl 60 with a win here, an opportunity it won't surrender."

Pete Prisco, CBS Sports: 49ers 31, Seahawks 27

"The winner of this game gets the top seed in the NFC. The Seahawks are built with a strong defense, while the 49ers have an explosive offense. Brock Purdy has been on fire. Look for that to continue here, but Seattle will stay in it against a bad 49ers defense. In the end, Purdy will make the plays to win it."

More Picks From Around The Web

Mike Florio, NBC Sports: 49ers 27, Seahawks 24

Chris Simms, NBC Sports: Seahawks 28, 49ers 24

Pamela Maldonado, ESPN: 49ers 35, Seahawks 31

Seth Walder, ESPN: Seahawks 27, 49ers 24

Eric Moody, ESPN: 49ers 23, Seahawks 17

The Seahawks kicked off the New Year with a practice at the Virginia Mason Athletic Center on January 1, 2026.

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