Brady Henderson, ESPN.com: 49ers 26, Seahawks 20
What to watch for: How much will Marshawn Lynch play? Pete Carroll said the Seahawks will "lean on" rookie sixth-round pick Travis Homer, who was their only healthy tailback before they re-signed former Seahawks Lynch and Robert Turbin this week. But even with a long layoff, Lynch might still be Seattle's best option.
Pete Prisco, CBSSports.com: Seahawks 25, 49ers 21
This is for the division title. The Seahawks beat the 49ers in the last meeting, but this Seattle team is banged up in a big way and hasn't been playing well. But I think this will be a game where Russell Wilson shows off his special skills and pulls off a big victory to win the division.
Nick Wagoner, ESPN.com: 49ers 30, Seahawks 24
Bold prediction: Niners defensive end Nick Bosa will put the finishing touches on a splendid rookie season with at least two sacks on his way to Defensive Rookie of the Year honors. The Seahawks will be missing standout left tackle Duane Brown, which means Bosa should have enough favorable matchups to dominate on a huge stage.
Tadd Haislop, SportingNews.com: 49ers 30, Seahawks 20
The NFL made the easy call to flex this matchup into the "Sunday Night Football" window and tee it up as the last regular-season game of the year. The scenario is simple: This is the NFC West championship game, and while the winner will get a top three seed in the playoffs (potentially the No. 1 overall seed and/or a first-round bye), the loser will be forced to hit the road for the wild-card round. Both teams are banged up, but the Seahawks' newest injuries (namely those to Chris Carson and Duane Brown) are particularly impactful. San Francisco will avenge its Week 10 loss to Seattle and clinch home-field advantage throughout the NFC playoffs.
Gregg Rosenthal, NFL.com: 49ers 31, Seahawks 27
Jadeveon Clowney has seemingly been waiting for this moment to return to the lineup, and Russell Wilson is plenty capable of pulling off a home upset despite awful pass protection recently. My pick here follows logic, not magic. This 49ers roster is deeper and allows for more ways to win, but logic often flies out the window in Seattle. Just sit back and enjoy the most compelling Sunday Night Football finale NBC has ever seen.
Michael David Smith, ProFootballTalk.com: 49ers 28, Seahawks 24
MDS: The regular-season game of the year will determine the NFC West champion, and I like the 49ers to go to Seattle and earn a hard-fought win. The road to the Super Bowl in the NFC will go through San Francisco.
Michael Florio, ProFootballTalk.com: 49ers 27, Seahawks 24
Florio's take: The NFL has saved the best for last, with a division title, the top seed in the NFC for the 49ers, and a bye (possibly) for the Seahawks riding on the outcome.
Cody Benjamin, CBSSports.com: Seahawks 34, 49ers 31
Man, this one's tough. Seattle is really banged up, and the Niners could zero in on getting after Russell Wilson. They've also been quietly shaky in terms of allowing points here and there, and Wilson, in prime time, is still safer than Jimmy Garoppolo.
Sam Farmer, Los Angeles Times: 49ers 31, Seahawks 27
Signing Marshawn Lynch is interesting, but can the Seahawks rekindle a running game after suffering the blows they have? San Francisco should make enough plays to hang on and win this one.
More Picks From Around The Web
Four of the ten polled so far at ESPN.com side with the Seahawks this Sunday.
Two of seven writers at USA Today pick the Seahawks coming out on top on Sunday.
Three of eight experts at CBSSports.com chose the Seahawks as victors this Sunday.
The Seahawks and the 49ers will meet this Sunday at CenturyLink Field for the final week of the 2019 regular season to decide the winner of the NFC West. Take a look back at photos from past games between the two teams.
Seattle Seahawks fullback Dan Doornink (33) runs upfield during an NFL game against the San Francisco 49ers in San Francisco, Oct. 7, 1979. The Seahawks defeated the 49ers 35-24. (AP Photo/Al Messerschmidt)
San Francisco quarterback Joe Montana (16) passes during an NFL football game against Seattle Seahawks on Sunday, Nov. 25, 1985, in San Francisco. The 49ers won the game, 19-6. (AP Photo/Greg Trott)
Seattle Seahawks linebacker Brian Bosworth (55) stands with defensive lineman Jacob Green (79) during an NFL preseason football game in 1988 in San Francisco. (AP Photo/Greg Trott)
San Francisco 49ers Steve Young plays in a game against the Seattle Seahawks at Candlestick Park in San Francisco, CA. August 15, 1991. ( AP Photo/Tom DiPace)
San Francisco 49ers vs. Seattle Seahawks at Candlestick Park Saturday, August 9, 1997. 49ers beat Seahawks 21-17 in a preseason game. San Francisco 49ers quarterback Jeff Brohm (11). (AP Photo/Al Golub)
San Francisco 49ers vs. Seattle Seahawks at Candlestick Park Saturday, August 9, 1997. 49ers beat Seahawks 21-17 in a preseason game. Seattle Seahawks linebacker Dean Wells (95) attempts to stop San Francisco 49ers running back Terry Kirby (41). (AP Photo/Al Golub)
Seattle Seahawks wide receiver James McKnight (82) catches a 21-yard touchdown pass from quarterback Warren Moon in the second quarter of their game against the San Francisco 49ers Sunday, Dec. 21, 1997, in Seattle. Defending on the play is San Francisco's Merton Hanks (36). (AP Photo/Elaine Thompson)
Seattle Seahawks defensive back Marcus Robertson (31) gets ready to make sure San Francisco 49ers running back Garrison Hearst (20) is stopped on Sunday, December 1, 2002, in San Francisco, California. The 49ers defeated the Seahawks 31-24. (AP Photo/Al Golub)
Seattle Seahawks quarterback Matt Hasselbeck (8) is seen in action during an NFL game against the San Francisco 49ers, Sunday, Dec. 1, 2002, in San Francisco. (Allen Kee via AP)
Seattle Seahawks defensive back Reggie Tongue (25) moves in to finish off tackle on San Francisco 49ers wide receiver Tai Streets (89) on Sunday, December 1, 2002, in San Francisco, California. The 49ers defeated the Seahawks 31-24. (AP Photo/Al Golub)
San Francisco 49ers defensive back Tony Parrish (33) moves in to stop Seattle Seahawks running back Shaun Alexander (37) on Saturday, December 27, 2003, in San Francisco, California. The Seahawks defeated the 49ers 24-17. (AP Photo/Al Golub)
San Francisco 49ers defensive end John Engelberger (95) rushes Seattle Seahawks quarterback Matt Hasselbeck (8) on Saturday, December 27, 2003, in San Francisco, California. The Seahawks defeated the 49ers 24-17. (AP Photo/Al Golub)
Seattle Seahawks' Antonio Cochran (78) celebrates a fumble recovery by teammate safety Ken Hamlin on the first play after the 2-minute warning in the fourth quarter against the San Francisco 49ers, Sunday, Oct. 12, 2003, in Seattle. The Seahawks won 20-19. At left is 49ers' Ron Stone. (AP Photo/Elaine Thompson)
Seattle Seahawks' Ken Lucas (21) grabs San Francisco 49ers Jamal Robertson on a run in the fourth quarter Sunday, Sept. 26, 2004, in Seattle. Robertson was held to no gain on the play, and the Seahawks won, 34-0. (AP Photo/Elaine Thompson)
Aerial view of Seattle Seahawks opening day game vs San Francisco 49ers, at Qwest Field in Seattle on Sunday, Sept. 26, 2004. (AP Photo/Julia Robertson)
Seattle Seahawks defensive tackle Cedric Woodard celebrates with the ball along with Grant Wistrom, center, and Chike Okeafor, right, after recovering a fumble by the San Francisco 49ers in the first half in Seattle, Sunday, Sept. 26, 2004. The Seahawks won, 34-0. (AP Photo/John Froschauer)
San Francisco 49ers' Derek Smith, left, and Seattle Seahawks' Ryan Hannam collide during a play in the first half, Sunday, Dec. 11, 2005, in Seattle. The Seahawks won, 41-3. (AP Photo/Elaine Thompson)
Seattle Seahawks running back Shaun Alexander (37) celebrates after a rushing touchdown against the San Francisco 49ers in the first half on Sunday, Nov. 20, 2005, in San Francisco, Calif. (AP Photo/Marcio Jose Sanchez)
Seattle Seahawks running back Shaun Alexander (37) runs against the San Francisco 49ers in the first quarter Thursday, Dec. 14, 2006, at Qwest Field in Seattle. (AP Photo/Ted S. Warren)
Seattle Seahawks wide receiver Darrell Jackson, left, hauls in a 41-yard touchdown pass past San Francisco 49ers safety Mark Roman (26) in the fourth quarter of an NFL football game in San Francisco, Sunday, Nov. 19, 2006. San Francisco won 20-14. (AP Photo/Marcio Jose Sanchez)
Seattle Seahawks running back Shaun Alexander, left, and San Francisco 49ers running back Frank Gore embrace at the end of a 20-14 win by the 49ers in an NFL football game in San Francisco, Sunday, Nov. 19, 2006.(AP Photo/\Jeff Chiu)
Seattle Seahawks Lofa Tatupu tackles San Francisco 49ers wide receiver Darrell Jackson during their NFL football game in San Francisco, Sunday, Sept. 30, 2007. (AP Photo/Jeff Chiu)
Seattle Seahawks' Shaun Alexander jumps between San Francisco 49ers' Patrick Willis, left, and Mark Roman, right, during the third quarter of an NFL football game in San Francisco, Sunday, Sept. 30, 2007. The Seahawks won 23-3. (AP Photo/Jeff Chiu)
Seattle Seahawks' D.J. Hackett (18) catches a pass in front of San Francisco 49ers' Walt Harris on a 46-yard play during the second quarter of an NFL football game Monday, Nov. 12, 2007, in Seattle. (AP Photo/Elaine Thompson)
Seattle Seahawks offensive lineman Walter Jones (71) blocks during an NFL game against the San Francisco 49ers, Sunday, Oct. 26, 2008 in San Francisco. (AP Photo/Greg Trott)
Seattle Seahawks' Michael Bumpus, left, returns a punt as San Francisco 49ers' Shawntae Spencer pursues him in the second half in an NFL football game Sunday, Sept. 14, 2008, in Seattle. The 49ers won 33-30 in overtime. (AP Photo/Elaine Thompson)
Seattle Seahawks quarterback Matt Hasselbeck (8) scrambles during an NFL game against the San Francisco 49ers, Sunday, Dec. 6, 2009 in Seattle. The Seahawks won the game, 20-17. (AP Photo/Greg Trott)
San Francisco 49ers wide receiver Josh Morgan (84) heads downfield as Seattle Seahawks linebacker David Hawthorne makes a tackle during an NFL game, Sunday, Dec. 6, 2009 in Seattle. The Seahawks won the game, 20-17. (AP Photo/Greg Trott)
Seattle Seahawks running back Marshawn Lynch (24) in action during the third quarter of an NFL football game in San Francisco, Sunday, Dec. 12, 2010. (AP Photo/Marcio Jose Sanchez)
The San Francisco 49ers play the Seattle Seahawks in an NFL football game in San Francisco, Sunday, Dec. 12, 2010. (AP Photo/Marcio Jose Sanchez)
Seattle Seahawks wide receiver Doug Baldwin (15) flies through the air for a first down during an NFL game against the San Francisco 49ers on Saturday, Dec. 24, 2011, in Seattle. The 49ers won the game, 19-17. (AP Photo/Greg Trott)
Seattle Seahawks running back Marshawn Lynch (24) scores on a 4-yard run during an NFL game after a San Francisco 49ers player was injured on Saturday, Dec. 24, 2011, in Seattle. The 49ers won the game, 19-17. (AP Photo/Greg Trott)
Seattle Seahawks running back Robert Turbin (22) is tackled by San Francisco 49ers inside linebacker Patrick Willis (52) during the NFL game between the San Francisco 49ers and the Seattle Seahawks on Sunday, December 23, 2012 in Seattle, Washington. (Photo Credit: AP Photo/Jon Ferrey)
Seattle Seahawks quarterback Russell Wilson (3) runs from San Francisco 49ers linebacker Aldon Smith (99) during the first half of an NFL football game in San Francisco, Thursday, Oct. 18, 2012. (AP Photo/Tony Avelar)
Seattle Seahawks quarterback Russell Wilson (3) during an NFL regular season game against the San Francisco 49ers on Sunday, Dec. 8, 2013 in San Francisco. The 49ers won the game, 19-17. (AP Photo/Ric Tapia)
Seattle Seahawks running back Marshawn Lynch (24) during an NFL game against the San Francisco 49ers on Sunday, Sep. 15, 2013 in Seattle. The Seahawks won the game, 29-3. (AP Photo/Ric Tapia)
FILE - In this Jan. 19, 2014, file photo, Seattle Seahawks' Richard Sherman (25) tips a pass in the end zone intended for San Francisco 49ers' Michael Crabtree (15) in the final minute of the second half of the NFC championship NFL football game in Seattle. Seattle's Malcolm Smith intercepted the tipped pass. Sherman was fined $7,875 for unsportsmanlike conduct/taunting after he made a choking gesture after the play toward the San Francisco bench that he said was directed at quarterback Colin Kaepernick. (AP Photo/Matt Slocum, File)
Seattle Seahawks quarterback Russell Wilson calls to his team at the line of scrimmage before a play against the San Francisco 49ers, Sunday, Dec. 14, 2014, in Seattle. (AP Photo/Elaine Thompson)
Seattle Seahawks running back Marshawn Lynch (24) leaps over the goal line for a touchdown during an NFL football game against the San Francisco 49ers at Levi's Stadium on Thursday October 22, 2015 in Santa Clara, California. Seattle won 20-3. (Aaron M. Sprecher via AP)
Seattle Seahawks wide receiver Tyler Lockett (16) and offensive guard Justin Britt, right, celebrate in front of back judge Scott Helverson, left, after Lockett scored a touchdown against the San Francisco 49ers in an NFL football game Sunday, Nov. 22, 2015, in Seattle. (AP Photo/Elaine Thompson)
Seattle Seahawks running back Christine Michael (32) runs the football during an NFL football game against the San Francisco 49ers, Sunday, Sept. 25, 2016, in Seattle. The Seahawks defeated the 49ers, 37-18. (Ryan Kang via AP)
FILE - In this Sunday, Nov. 26, 2017, file photo, Seattle Seahawks tight end Jimmy Graham (88) celebrates after a touchdown reception against the San Francisco 49ers during the second half of an NFL football game in Santa Clara, Calif. Graham is on a run of touchdowns unlike any other point in his three seasons with the Seahawks. He leads NFC tight ends with eight TDs, six coming in the past five games. (AP Photo/Don Feria, File)
Seattle Seahawks quarterback Russell Wilson (3) scores a touchdown against the San Francisco 49ers during the first half of an NFL football game Sunday, Nov. 26, 2017, in Santa Clara, Calif. (AP Photo/John Hefti)
San Francisco 49ers quarterback Nick Mullens drops back to pass against the Seattle Seahawks during an NFL football game in Santa Clara, Calif., Sunday, Dec. 16, 2018. (AP Photo/Tony Avelar)
Seattle Seahawks wide receiver Doug Baldwin (89) is congratulated by offensive tackle Duane Brown (76) after catching a touchdown pass against the San Francisco 49ers during the first half of an NFL football game in Santa Clara, Calif., Sunday, Dec. 16, 2018. (AP Photo/Ben Margot)
Seattle Seahawks wide receiver Jaron Brown, (18) celebrates with wide receiver David Moore (83) after Brown caught a pass for a touchdown during the second half of an NFL football game against the San Francisco 49ers, Sunday, Dec. 2, 2018, in Seattle. (AP Photo/John Froschauer)
San Francisco 49ers quarterback Jimmy Garoppolo, left, avoids being sacked by Seattle Seahawks defensive end Jadeveon Clowney (90) during the second half of an NFL football game in Santa Clara, Calif., Monday, Nov. 11, 2019. (AP Photo/Tony Avelar)
Seattle Seahawks tight end Jacob Hollister (48) celebrates after scoring against the San Francisco 49ers during the second half of an NFL football game in Santa Clara, Calif., Monday, Nov. 11, 2019. (AP Photo/Ben Margot)
Seattle Seahawks kicker Jason Myers, left, celebrates after kicking the winning field goal during overtime of an NFL football game against the San Francisco 49ers in Santa Clara, Calif., Monday, Nov. 11, 2019. Seattle won 27-24. (AP Photo/Tony Avelar)
