Brady Henderson, ESPN.com: 49ers 26, Seahawks 20
What to watch for: How much will Marshawn Lynch play? Pete Carroll said the Seahawks will "lean on" rookie sixth-round pick Travis Homer, who was their only healthy tailback before they re-signed former Seahawks Lynch and Robert Turbin this week. But even with a long layoff, Lynch might still be Seattle's best option.
Pete Prisco, CBSSports.com: Seahawks 25, 49ers 21
This is for the division title. The Seahawks beat the 49ers in the last meeting, but this Seattle team is banged up in a big way and hasn't been playing well. But I think this will be a game where Russell Wilson shows off his special skills and pulls off a big victory to win the division.
Nick Wagoner, ESPN.com: 49ers 30, Seahawks 24
Bold prediction: Niners defensive end Nick Bosa will put the finishing touches on a splendid rookie season with at least two sacks on his way to Defensive Rookie of the Year honors. The Seahawks will be missing standout left tackle Duane Brown, which means Bosa should have enough favorable matchups to dominate on a huge stage.
Tadd Haislop, SportingNews.com: 49ers 30, Seahawks 20
The NFL made the easy call to flex this matchup into the "Sunday Night Football" window and tee it up as the last regular-season game of the year. The scenario is simple: This is the NFC West championship game, and while the winner will get a top three seed in the playoffs (potentially the No. 1 overall seed and/or a first-round bye), the loser will be forced to hit the road for the wild-card round. Both teams are banged up, but the Seahawks' newest injuries (namely those to Chris Carson and Duane Brown) are particularly impactful. San Francisco will avenge its Week 10 loss to Seattle and clinch home-field advantage throughout the NFC playoffs.
Gregg Rosenthal, NFL.com: 49ers 31, Seahawks 27
Jadeveon Clowney has seemingly been waiting for this moment to return to the lineup, and Russell Wilson is plenty capable of pulling off a home upset despite awful pass protection recently. My pick here follows logic, not magic. This 49ers roster is deeper and allows for more ways to win, but logic often flies out the window in Seattle. Just sit back and enjoy the most compelling Sunday Night Football finale NBC has ever seen.
Michael David Smith, ProFootballTalk.com: 49ers 28, Seahawks 24
MDS: The regular-season game of the year will determine the NFC West champion, and I like the 49ers to go to Seattle and earn a hard-fought win. The road to the Super Bowl in the NFC will go through San Francisco.
Michael Florio, ProFootballTalk.com: 49ers 27, Seahawks 24
Florio's take: The NFL has saved the best for last, with a division title, the top seed in the NFC for the 49ers, and a bye (possibly) for the Seahawks riding on the outcome.
Cody Benjamin, CBSSports.com: Seahawks 34, 49ers 31
Man, this one's tough. Seattle is really banged up, and the Niners could zero in on getting after Russell Wilson. They've also been quietly shaky in terms of allowing points here and there, and Wilson, in prime time, is still safer than Jimmy Garoppolo.
Sam Farmer, Los Angeles Times: 49ers 31, Seahawks 27
Signing Marshawn Lynch is interesting, but can the Seahawks rekindle a running game after suffering the blows they have? San Francisco should make enough plays to hang on and win this one.
More Picks From Around The Web
Four of the ten polled so far at ESPN.com side with the Seahawks this Sunday.
Two of seven writers at USA Today pick the Seahawks coming out on top on Sunday.
Three of eight experts at CBSSports.com chose the Seahawks as victors this Sunday.
The Seahawks and the 49ers will meet this Sunday at State Farm Stadium in Arizona, their current home field, for Week 17 of the 2020 season. Take a look back at photos from past games between the two teams.
Seattle Seahawks' quarterback Jon Kitna (7) gets off a pass while under pressure of San Francisco 49ers' safety Tim McDonald Thursday, Aug. 19, 1999, during the first quarter of a pre-season game in San Francisco. (AP Photo/Ben Margot)
Seattle Seahawks wide receiver James McKnight (82) catches a 21-yard touchdown pass from quarterback Warren Moon in the second quarter of their game against the San Francisco 49ers Sunday, Dec. 21, 1997, in Seattle. Defending on the play is San Francisco's Merton Hanks (36). (AP Photo/Elaine Thompson)
San Francisco 49ers running back Roger Craig looks for a hole through Seattle Seahawks defenders during the first quarter of action on Friday, August 31, 1990 at Candlestick Park, San Francisco. At right is Seahawks linebacker Rufus Porter (97). (AP Photo/Paul Sakuma)
Seattle Seahawks running back Ricky Watters (32) evades San Francisco 49ers' Monty Montgomery on a first-quarter run Saturday, Aug. 19, 2000, in Seattle. Watters made a first down on the play. (AP Photo/Elaine Thompson)
San Francisco 49ers quarterback Steve Young of the NFC squad is under pressure by nose tackle Cortez Kennedy of the Seattle Seahawks in the first quarter of the Pro Bowl at the Aloha Stadium in Honolulu, Hawaii, Feb. 7, 1993. (AP Photo/Paul Sakuma)
In the fourth quarter, Trevone Boykin entered the game for Russell Wilson.
Russell Wilson scrambles for yardage during the first half.
In his first regular season game as a Seahawk, Cliff Avril stripped the ball from San Francisco quarterback Colin Kaepernick and Seattle recovered the fumble. Avril had a big year for the Seahawks, recording 9 1/2 sacks on the season.
Safety Kam Chancellor returns Seattle's third interception of the night.
Seahawks running back Marshawn Lynch pauses before crossing the goal line with his third touchdown of the game.
Even after the weather delay, threatening skies continued over Century Link Field.
Seahawks cornerback Richard Sherman skies to intercept a deep pass intented for San Francisco's Vernon Davis along the Seattle sideline as head coach Pete Carroll (lower right) watches.
Defensive end Frank Clark corrals the loose ball.
Seahawks receiver Doug Baldwin catches a five-yard touchdown pass in the corner of the end zone for Seattle's first score.
Seattle's Tyler Lockett opened the second half with an 84-yard kickoff return.
Seahawks tight end Jacob Hollister makes a falling, one-handed grab in the end zone for a touchdown in the third quarter.
Seahawks Branden Jackson and Poona Ford celebrate after Ford recovered a fumble caused by teammate Jadeveon Clowney.
Seahawks defensive teammates Tre Flowers, Bradley McDougald, Jarran Reed and Branden Jackson celebrate with Quandre Diggs after his first interception with the team.
Seahawks cornerback Shaquill Griffin knocks away a pass intended for the 49ers Marquise Goodwin in the first half.
Seattle's DK Metcalf stiff-arms San Francisco's Dre Greenlaw and heads upfield.
Seahawks defensive tackle Jarran Reed strips the ball away from 49ers quarterback Jimmy Garoppolo as Seattle's Poona Ford closes in.
A military veteran flips the opening coin toss as captains from both teams watch.
Seahawks kicker Jason Myers reacts after making a 46-yard field goal to tie the game with less than two minutes left in regulation.
A jubilant Jason Myers is lifted into the air by joyous teammates Geno Smith and Germain Ifedi after his game-winning field goal in overtime.
Seahawks quarterback Russell Wilson and 49ers cornerback Richard Sherman, both former teammates in Seattle, traded signed jerseys after the game.
Seahawks running back Marshawn Lynch found room for a five-yard gain on his first carry back with the team.
Seahawks linebacker K.J. Wright hits 49ers running back Matt Breida in the backfield that was ruled an incomplete pass after being reviewed by officials.
Receiver Tyler Lockett is brought down at the end of a 10-yard gain in the second quarter.
Seahawks running back Marshawn Lynch goes over the top of the blocks by Jamarco Jones and Mike Iupati to score a touchdown in the fourth quarter.
Seahawks receiver Tyler Lockett celebrates after his touchdown reception in the third quarter.
Former teammates with the Seahawks, Marshawn Lynch and the 49ers Richard Sherman chat during a break in the action.
