Brady Henderson, ESPN.com: 49ers 26, Seahawks 20
What to watch for: How much will Marshawn Lynch play? Pete Carroll said the Seahawks will "lean on" rookie sixth-round pick Travis Homer, who was their only healthy tailback before they re-signed former Seahawks Lynch and Robert Turbin this week. But even with a long layoff, Lynch might still be Seattle's best option.
Pete Prisco, CBSSports.com: Seahawks 25, 49ers 21
This is for the division title. The Seahawks beat the 49ers in the last meeting, but this Seattle team is banged up in a big way and hasn't been playing well. But I think this will be a game where Russell Wilson shows off his special skills and pulls off a big victory to win the division.
Nick Wagoner, ESPN.com: 49ers 30, Seahawks 24
Bold prediction: Niners defensive end Nick Bosa will put the finishing touches on a splendid rookie season with at least two sacks on his way to Defensive Rookie of the Year honors. The Seahawks will be missing standout left tackle Duane Brown, which means Bosa should have enough favorable matchups to dominate on a huge stage.
Tadd Haislop, SportingNews.com: 49ers 30, Seahawks 20
The NFL made the easy call to flex this matchup into the "Sunday Night Football" window and tee it up as the last regular-season game of the year. The scenario is simple: This is the NFC West championship game, and while the winner will get a top three seed in the playoffs (potentially the No. 1 overall seed and/or a first-round bye), the loser will be forced to hit the road for the wild-card round. Both teams are banged up, but the Seahawks' newest injuries (namely those to Chris Carson and Duane Brown) are particularly impactful. San Francisco will avenge its Week 10 loss to Seattle and clinch home-field advantage throughout the NFC playoffs.
Gregg Rosenthal, NFL.com: 49ers 31, Seahawks 27
Jadeveon Clowney has seemingly been waiting for this moment to return to the lineup, and Russell Wilson is plenty capable of pulling off a home upset despite awful pass protection recently. My pick here follows logic, not magic. This 49ers roster is deeper and allows for more ways to win, but logic often flies out the window in Seattle. Just sit back and enjoy the most compelling Sunday Night Football finale NBC has ever seen.
Michael David Smith, ProFootballTalk.com: 49ers 28, Seahawks 24
MDS: The regular-season game of the year will determine the NFC West champion, and I like the 49ers to go to Seattle and earn a hard-fought win. The road to the Super Bowl in the NFC will go through San Francisco.
Michael Florio, ProFootballTalk.com: 49ers 27, Seahawks 24
Florio's take: The NFL has saved the best for last, with a division title, the top seed in the NFC for the 49ers, and a bye (possibly) for the Seahawks riding on the outcome.
Cody Benjamin, CBSSports.com: Seahawks 34, 49ers 31
Man, this one's tough. Seattle is really banged up, and the Niners could zero in on getting after Russell Wilson. They've also been quietly shaky in terms of allowing points here and there, and Wilson, in prime time, is still safer than Jimmy Garoppolo.
Sam Farmer, Los Angeles Times: 49ers 31, Seahawks 27
Signing Marshawn Lynch is interesting, but can the Seahawks rekindle a running game after suffering the blows they have? San Francisco should make enough plays to hang on and win this one.
More Picks From Around The Web
Four of the ten polled so far at ESPN.com side with the Seahawks this Sunday.
Two of seven writers at USA Today pick the Seahawks coming out on top on Sunday.
Three of eight experts at CBSSports.com chose the Seahawks as victors this Sunday.
The Seahawks and the 49ers will meet this Sunday at CenturyLink Field for Week 8 of the 2020 season. Take a look back at photos from past games between the two teams.