Brady Henderson,*ESPN.com*: Seahawks 30, Cardinals 21
What to watch for: Keep an eye on Seahawks linebacker Shaquem Griffin chasing Kyler Murray. Griffin has become a regular in the Seahawks' pass-rush rotation over the past five games, and Pete Carroll gave what seemed like a hint that he could factor heavily into this game because of how his speed matches with that of Murray.
Pete Prisco,*CBSSports.com*: Seahawks 27, Cardinals 20
The Seahawks are the top seed in the NFC right now, and this game is big to try and achieve that. The Cardinals looked better on offense against the Browns, but this will be a tough challenge. Seattle is pushing for a lot more in this one, and that drive will be the difference. Russell Wilson and gang stay as the top seed.
Josh Weinfuss,*ESPN.com*: Seahawks 27, Cardinals 24
Bold prediction: Murray will throw for two touchdowns and run for another while proving that the noise in Seattle isn't too much for him. But the Seahawks will win on a last-second field goal. -- Josh Weinfuss
Tadd Haislop,*SportingNews.com:*Seahawks 28, Cardinals 20
The Seahawks shouldn't lose to the Cardinals. Then again, the 49ers weren't supposed to lose to the Falcons last week, either. For that reason, Seattle can't afford to let this become a trap game ahead of its Week 17 rematch (and likely NFC West title game) against San Francisco. Thanks to great matchups across the board against the Cardinals' struggling defense, the Seahawks should be just fine and will stick as the No. 1 seed for at least one more week.
Gregg Rosenthal,*NFL.com*: Seahawks 28, Cardinals 20
The only Seahawks win by more than one score all season came in Arizona, so I don't blame the 12s for being confident this week. Even if Patrick Peterson is finally playing well again, Russell Wilson and friends should be able to rack up stats against this porous Cardinals secondary. The game could feature its usual Seahawkian complications, however, if Pete Carroll's squad doesn't have Jadeveon Clowney and Ezekiel Ansah back. Give Kyler Murray time, and he's liable to make the home crowd uncomfortable in the fourth quarter, like it has been in every other home game this season.
Michael David Smith,*ProFootballTalk.com*: Seahawks 34, Cardinals 20
MDS: The Seahawks are heading for a Week 17 showdown with the 49ers, and they won't let the Cardinals get in their way.
Michael Florio,*ProFootballTalk.com*: Seahawks 31, Cardinals 17
Florio's take: The table is set for the Seahawks to nail down the No. 1 or No. 2 seed; they simply need to win their last two games, both at home.
Cody Benjamin,*CBSSports.com*: Seahawks 30, Cardinals 23
Kyler Murray and Kenyan Drake make for an exciting QB-RB duo under Kliff Kingsbury, and Arizona has a future. The Seahawks are still playing for something, though, and they shouldn't have trouble getting up and down the field at home.
Sam Farmer,*Los Angeles Times*: Seahawks 34, Cardinals 21
The Seahawks have the chance to be the No. 1 seed, so they're hungry. Seattle is a really difficult place to play. The Cardinals have won some games, but they're still in the early stages of a turnaround.
More Picks From Around The Web
Nine of the ten polled so far at ESPN.com side with the Seahawks this Sunday.
Seven of seven writers at USA Today pick the Seahawks coming out on top on Sunday.
Four of eight experts at CBSSports.com chose the Seahawks as victors this Sunday.
Take a look back at photos from previous games between the Seattle Seahawks and Arizona Cardinals.
Phoenix Cardinals quarterback Gary Hogeboom can't find a receiver due to heavy defensive pressure from Seattle Seahawks (92) David Wyman and (72) Joe Nash during action in their pre-season game, Aug. 12, 1989 in Tempe, Arizona. The Seahawks proved too much for the Cardinals after the game went into overtime and lost 16-10. (AP Photo/Chad Surmick)
Seattle Seahawks' Shaun Alexander (37) tries to get past Arizona Cardinals defender Ronald McKinnon (57) in the second quarter of a a pre-season game Saturday, Aug. 18, 2001, in Seattle. (AP Photo/Elaine Thompson)
Seattle Seahawks coach Mike Holmgren, left, and Arizona Cardinals coach Vince Tobin, right, walk off the field after the Cardinals defeated the Seahawks 21-3 in a preseason game Saturday, Aug. 12, 2000, at Sun Devil Stadium in Tempe, Ariz. (AP Photo/Roy Dabner)
Seattle Seahawks quarterback Trent Dilfer greets Arizona Cardinals cornerback Duane Starks following their game Sunday, Sept. 15, 2002, in the team's new stadium in Seattle. Arizona won, 24-13. (AP Photo/Elaine Thompson)
Seattle Seahawks' Chike Okeafir (56) strips the ball away from Arizona Cardinals quarterback Josh McCown during the first quarter Sunday, Oct. 24, 2004 at Sun Devil Stadium in Tempe, Ariz. (AP Photo/Matt York)
Arizona Cardinals' Emmitt Smith (22) is brought down by Seattle Seahawks' Orlando Huff, back, and Ken Lucas, right, during the second quarter in Seattle Sunday Dec. 26, 2004. Smith rushed for 65 yards in the 24-21 win for the Seahawks. (AP Photo/John Froschauer)
Seattle Seahawks' Shaun Alexander changes directions on Arizona Cardinals' Ifeanyi Ohalete during the second quarter in Seattle Sunday Dec. 26, 2004. Alexander completed the day scoring three touchdowns and rushing for 145 yards in the 24-21 win for the Seahawks. (AP Photo/John Froschauer)
Seattle Seahawks' Shaun Alexander, left, and Arizona Cardinals quarterback Josh McCown talk after the game that Seattle won 24-21 with Alexander scoring three touchdowns in Seattle, Sunday Dec. 26, 2004. (AP Photo/John Froschauer)
FILE - In this Sept. 13, 1998, file photo, Arizona Cardinals' Chris Gedney (84) takes in a pass while in the grasp of Seattle Seahawks' Fred Thomas (22) and goes for a touchdown in the fourth quarter of an NFL football game in Seattle. Gendey, an All-American tight end at Syracuse who played in the NFL for the Chicago Bears and Cardinals, has died, Syracuse University announced Friday, March 9, 2018. He was 47. (AP Photo/Jay Drowns, File)
Running back Ron Moore (30) of the Phoenix Cardinals is held to a one yard gain as he is tackled by Cortez Kennedy (96) of the Seattle Seahawks during the third quarter of their NFL game in Seattle, Washington, Dec. 19, 1993. Watching the play is Joe Wolf (68) of the Cardinals. Phoenix beat Seattle in overtime, 30-27. (AP Photo/Bill Chan)
Seattle Seahawks running back Marshawn Lynch (24) runs for a 33-yard touchdown past Arizona Cardinals strong safety Rashad Johnson (49) and inside linebacker Daryl Washington (58) during the third quarterof an NFL football game in Seattle, Sunday, Dec. 9, 2012. (AP Photo/Stephen Brashear)
Seattle Seahawks quarterback Russell Wilson (3) during the first quarter of an NFL football game against the Arizona Cardinals, Sunday, Dec. 21, 2014 in Glendale, Ariz. (AP Photo/Rick Scuteri)
Referee Walt Coleman tosses the coin before an NFL football game between the Seattle Seahawks and the Arizona Cardinals, Sunday, Dec. 31, 2017, in Seattle. (AP Photo/Elaine Thompson)
Arizona Cardinals outside linebacker Chandler Jones (55) and Seattle Seahawks offensive tackle Duane Brown battle during the first half of an NFL football game, Thursday, Nov. 9, 2017, in Glendale, Ariz. (AP Photo/Rick Scuteri)
Seattle Seahawks running back Chris Carson (32) rushes past Arizona Cardinals linebacker Kylie Fitts, left, during the first half of an NFL football game, Sunday, Dec. 22, 2019, in Seattle. (AP Photo/Elaine Thompson)
Seattle Seahawks outside linebacker K.J. Wright (50) celebrates during an NFL football game against the Arizona Cardinals, Sunday, Dec. 22, 2019, in Seattle. The Cardinals defeated the Seahawks, 27-13. (Ryan Kang via AP)
