Brady Henderson,*ESPN.com*: Seahawks 30, Cardinals 21
What to watch for: Keep an eye on Seahawks linebacker Shaquem Griffin chasing Kyler Murray. Griffin has become a regular in the Seahawks' pass-rush rotation over the past five games, and Pete Carroll gave what seemed like a hint that he could factor heavily into this game because of how his speed matches with that of Murray.
Pete Prisco,*CBSSports.com*: Seahawks 27, Cardinals 20
The Seahawks are the top seed in the NFC right now, and this game is big to try and achieve that. The Cardinals looked better on offense against the Browns, but this will be a tough challenge. Seattle is pushing for a lot more in this one, and that drive will be the difference. Russell Wilson and gang stay as the top seed.
Josh Weinfuss,*ESPN.com*: Seahawks 27, Cardinals 24
Bold prediction: Murray will throw for two touchdowns and run for another while proving that the noise in Seattle isn't too much for him. But the Seahawks will win on a last-second field goal. -- Josh Weinfuss
Tadd Haislop,*SportingNews.com:* Seahawks 28, Cardinals 20
The Seahawks shouldn't lose to the Cardinals. Then again, the 49ers weren't supposed to lose to the Falcons last week, either. For that reason, Seattle can't afford to let this become a trap game ahead of its Week 17 rematch (and likely NFC West title game) against San Francisco. Thanks to great matchups across the board against the Cardinals' struggling defense, the Seahawks should be just fine and will stick as the No. 1 seed for at least one more week.
Gregg Rosenthal,*NFL.com*: Seahawks 28, Cardinals 20
The only Seahawks win by more than one score all season came in Arizona, so I don't blame the 12s for being confident this week. Even if Patrick Peterson is finally playing well again, Russell Wilson and friends should be able to rack up stats against this porous Cardinals secondary. The game could feature its usual Seahawkian complications, however, if Pete Carroll's squad doesn't have Jadeveon Clowney and Ezekiel Ansah back. Give Kyler Murray time, and he's liable to make the home crowd uncomfortable in the fourth quarter, like it has been in every other home game this season.
Michael David Smith,*ProFootballTalk.com*: Seahawks 34, Cardinals 20
MDS: The Seahawks are heading for a Week 17 showdown with the 49ers, and they won't let the Cardinals get in their way.
Michael Florio,*ProFootballTalk.com*: Seahawks 31, Cardinals 17
Florio's take: The table is set for the Seahawks to nail down the No. 1 or No. 2 seed; they simply need to win their last two games, both at home.
Cody Benjamin,*CBSSports.com*: Seahawks 30, Cardinals 23
Kyler Murray and Kenyan Drake make for an exciting QB-RB duo under Kliff Kingsbury, and Arizona has a future. The Seahawks are still playing for something, though, and they shouldn't have trouble getting up and down the field at home.
Sam Farmer,*Los Angeles Times*: Seahawks 34, Cardinals 21
The Seahawks have the chance to be the No. 1 seed, so they're hungry. Seattle is a really difficult place to play. The Cardinals have won some games, but they're still in the early stages of a turnaround.
More Picks From Around The Web
Nine of the ten polled so far at ESPN.com side with the Seahawks this Sunday.
Seven of seven writers at USA Today pick the Seahawks coming out on top on Sunday.
Four of eight experts at CBSSports.com chose the Seahawks as victors this Sunday.
The Seahawks and the Cardinals will meet this Sunday at the CenturyLink Field for Week 16 of the 2019 season. Take a look back at photos from past games between the two teams.
Seattle Seahawks running back Curt Warner (28) takes a handoff during an NFL game against the St. Louis Cardinals on November 13, 1983. The Cardinals defeated the Seahawks 33-28. (Peter Read Miller via AP)
Phoenix Cardinals quarterback Gary Hogeboom can't find a receiver due to heavy defensive pressure from Seattle Seahawks (92) David Wyman and (72) Joe Nash during action in their pre-season game, Aug. 12, 1989 in Tempe, Arizona. The Seahawks proved too much for the Cardinals after the game went into overtime and lost 16-10. (AP Photo/Chad Surmick)
Running back Ron Moore (30) of the Phoenix Cardinals is held to a one yard gain as he is tackled by Cortez Kennedy (96) of the Seattle Seahawks during the third quarter of their NFL game in Seattle, Washington, Dec. 19, 1993. Watching the play is Joe Wolf (68) of the Cardinals. Phoenix beat Seattle in overtime, 30-27. (AP Photo/Bill Chan)
Seattle Seahawks tight end Trey Junkin (83) runs a pass pattern during an NFL game against the Arizona Cardinals in Tempe, Oct. 29, 1995. The Cardinals defeated the Seahawks 20-14 at Sun Devil Stadium. (AP Photo/NFL Photos)
Arizona Cardinals' Chris Gedney (84) takes in a pass while in the grasp of Seattle Seahawks' Fred Thomas (22) and goes for a touchdown in the fourth quarter, Sept. 13, 1998 in Seattle. The play went 23 yards but wasn't enough as Seattle won the game 33-14. (AP Photo/Jay Drowns)
Arizona Cardinals outside linebacker LeVar Woods grabs Seattle Seahawks wide receiver Bobby Engram November 10, 2002 at Sun Devils Stadium. The Seahawks defeated the Cardinals 27 - 6. (AP Photo / Al Messerschmidt)
Arizona Cardinals running back Marcel Shipp (31) is surrounded by Seattle Seahawks defenders November 10, 2002 at Sun Devils Stadium. The Seahawks defeated the Cardinals 27 - 6. (AP Photo / Al Messerschmidt)
Seattle Seahawks' Itula Mili catches a 1-yard pass in the endzone from quarterback Trent Dilfer while Arizona Cardinals' Kwamie Lassiter stands in the background during the second quarter in Seattle Sunday Sept. 15, 2002. AP Photo/John Froschauer)
Seattle Seahawks' Shaun Alexander changes directions on Arizona Cardinals' Ifeanyi Ohalete during the second quarter in Seattle Sunday Dec. 26, 2004. Alexander completed the day scoring three touchdowns and rushing for 145 yards in the 24-21 win for the Seahawks. (AP Photo/John Froschauer)
Arizona Cardinals Josh McCown (12) makes a play with the football vs the Seattle Seahawks Sunday December 26, 2004. in Seattle WA. (AP Photo/Kevin Reece)
Seattle Seahawks' Ken Hamlin, left, stops Arizona Cardinals running back Emmitt Smith after a short gain in the second quarter Sunday, Oct. 24, 2004, in Tempe, Ariz. (AP Photo/Matt York)
Seattle Seahawks wide receiver Peter Warrick, right, signals the first down after catching a pass for a first down in the fourth quarter, as Arizona Cardinals free safety Robert Griffith (34) reacts Sunday, Sept. 25, 2005, at Qwest Field in Seattle. The Seahawks won, 37-12. (AP Photo/Ted S. Warren)
Seattle Seahawks' D.J. Hackett celebrates his touchdown during the second quarter against the Arizona Cardinals during their football game Sunday, Dec. 10, 2006 in Glendale, Ariz. (AP Photo/Rick Scuteri)
Seattle Seahawks Shaun Alexander (37) makes a play with the football against the Arizona Cardinals Sunday November 6, 2005 in Tempe, AZ. (AP Photo/Kevin Reece)
Seattle Seahawks Leroy Hill (56) pulls down Arizona Cardinals quarterback Kurt Warner during the first quarter Sunday, Nov. 6, 2005 at Sun Devil Stadium in Tempe, Ariz. (AP Photo/Paul Connors)
Seattle Seahawks defensive end Grant Wistrom (98) celebrates with Kelly Herndon (31) after tackling Arizona Cardinals runningback J.J. Arrington (28) for a 2-yard loss during the second half in Seattle on Sunday, Sept. 25, 2005. Seattle won 37-12. (AP Photo/John Froschauer)
Arizona Cardinals running back Edgerrin James (32) scores a touchdown as Seattle Seahawks Leroy Hill, right, defends during the first quarter of their football game Sunday, Dec. 10, 2006. (AP Photo/Matt York,file)
Seattle Seahawks' Mack Strong (38) leaps over a defender on a first quarter, 14 yard run as Arizona Cardinals' Orlando Huff (57) moves in, Sunday, Sept. 17, 2006, in Seattle. The Seahawks won 21-10. (AP Photo/Elaine Thompson)
Seattle Seahawks punter Ryan Plackemeier kicks from the end zone against the Arizona Cardinals during the third quarter of a football game in Seattle, Saturday, Sept. 17, 2006. the Seahawks won 21-10. (AP Photo//John Froschauer)
Seattle Seahawks' Bobby Engram, left, holds up the ball as teammates Shaun Alexander (37) and Deion Branch join him in celebrating Engram's first quarter touchdown reception against the Arizona Cardinals in an NFL football game in this Dec. 9, 2007(AP Photo/Elaine Thompson, File)
Seattle Seahawks' Patrick Kerney, second right, is congratulated by teammates Brian Russell, right, and Brandon Mebane after Kerney's sack of Arizona Cardinals quarterback Kurt Warner (13) during the second half of an NFL football game Sunday, Dec. 9, 2007, in Seattle. The Seahawks won 42-21. (AP Photo/Elaine Thompson)
Seattle Seahawks' Julian Peterson motions to fans as he plays against the Arizona Cardinals during the second half of an NFL football game Sunday, Dec. 9, 2007, in Seattle. The Seahawks won 42-21. (AP Photo/Elaine Thompson)
Seattle Seahawks' Matt Hasselbeck (8) in action against the Arizona Cardinals on Sunday, Nov. 16, 2008, in Seattle. (AP Photo/Elaine Thompson)
Arizona Cardinals' Larry Fitzgerald (11) in action against the Seattle Seahawks Brian Russell (25) on Sunday, Nov. 16, 2008, in Seattle. (AP Photo/Elaine Thompson)
Seattle Seahawks' Deion Branch (83) makes a touchdown catch against Arizona Cardinals' Roderick Hood, right, in the second quarter of an NFL football game Sunday, Dec. 28, 2008 in Glendale, Ariz. (AP Photo/Ross D. Franklin)
Seattle Seahawks' Brian Russell, top right, and Kelly Jennings, bottom right, tackle Arizona Cardinals' Early Doucet (80) in the second quarter of an NFL football game Sunday, Dec. 28, 2008 in Glendale, Ariz. The Cardinals defeated the Seahawks 34-21. (AP Photo/Ross D. Franklin)
Seattle Seahawks' Roy Lewis (34) celebrates with teammates against the Arizona Cardinals during an NFL football game, Sunday, Oct. 18, 2009, in Seattle. (AP Photo/Ted S. Warren)
Arizona Cardinals Tim Hightower (34) in action against the Seattle Seahawks' during the first half of an NFL football game, Sunday, Oct. 18, 2009, in Seattle. (AP Photo/Ted S. Warren)
Seattle Seahawks running back Justin Forsett (20) is brought down by Arizona Cardinals cornerback Bryant McFadden, bottom, as Arizona Cardinals defensive end Calais Campbell (93) brings down Seattle Seahawks wide receiver T.J. Houshmandzadeh during the first half of an NFL football game Sunday, Nov. 15, 2009 in Glendale, Ariz. (AP Photo/Matt York)
Seattle Seahawks tight end John Carlson (89) scores a touchdown against the Arizona Cardinals during the first half of an NFL football game Sunday, Nov. 15, 2009, in Glendale, Ariz. (AP Photo/Matt York)
Seattle Seahawks wide receiver Mike Williams (17) pulls in a pass as Arizona Cardinals cornerback Dominique Rodgers-Cromartie defends during the first quarter of an NFL football game Sunday, Nov. 14, 2010, in Glendale, Ariz. (AP Photo/Paul Connors)
Seattle Seahawks linebacker Aaron Curry (59) celebrates a stop against the Arizona Cardinals during the second quarter of an NFL football game Sunday, Nov. 14, 2010, in Glendale, Ariz. (AP Photo/Ralph Freso)
Arizona Cardinals' Daryl Washington (58) and Greg Toler (28) try to stop Seattle Seahawks' Marshawn Lynch as lynch runs the ball in the second half of an NFL football game, Sunday, Oct. 24, 2010, in Seattle. (AP Photo/Ted S. Warren)
Seattle Seahawks quarterback Tarvaris Jackson sets to hand off the ball against the Arizona Cardinals in the first half of a NFL football game, Sunday, Sept. 25, 2011, in Seattle. (AP Photo/Ted S. Warren)
Seattle Seahawks' Kam Chancellor (31) celebrates with Leroy Hill, second from right, after intercepting against the Arizona Cardinals while Chester Taylor, right, walks down field late in the second half of a NFL football game, Sunday, Sept. 25, 2011, in Seattle. The Seahawks won 13-10. (AP Photo/Ted S. Warren)
Seattle Seahawks' Kam Chancellor, left, celebrates his interception as Arizona Cardinals quarterback Kevin Kolb (4) holds his head as he walks off the field late in the second half of a NFL football game, Sunday, Sept. 25, 2011, in Seattle. The Seahawks won 13-10. (AP Photo/Elaine Thompson)
Seattle Seahawks tight end Zach Miller (86) celebrates in front of Arizona Cardinals strong safety Rashad Johnson (49) after scoring on a 24-yard touchdown reception during the second quarter of an NFL football game in Seattle, Sunday, Dec. 9, 2012. (AP Photo/Stephen Brashear)
Seattle Seahawks wide receiver Sidney Rice makes the catch as Arizona Cardinals cornerback Patrick Peterson makes the tackle during the first half of an NFL football game, Sunday, Sept. 9, 2012, in Glendale, Ariz. (AP Photo/Matt York)
Seattle Seahawks strong safety Kam Chancellor, right, comes down with an interception of a pass intended for Arizona Cardinals tight end Rob Housler, lower left, in the first half of an NFL football game, Sunday, Dec. 22, 2013, in Seattle. (AP Photo/Elaine Thompson)
Seattle Seahawks Richard Sherman (25) comes up with the football as Seahawks' Earl Thomas (29) celebrates after Sherman intercepted an Arizona Cardinals pass in the second half of an NFL football game, Sunday, Dec. 22, 2013, in Seattle. (AP Photo/Elaine Thompson)
Referee Scott Green, center, talks to players from the Seattle Seahawks and the Arizona Cardinals during the coin flip before an NFL football game, Sunday, Dec. 22, 2013, in Seattle. (AP Photo/Elaine Thompson)
Seattle Seahawks quarterback Russell Wilson (3) runs in for a touchdown as teammate Doug Baldwin (89) signals touchdown as Arizona Cardinals defensive end Tommy Kelly (95) defends during the second half of an NFL football game, Sunday, Dec. 21, 2014, in Glendale, Ariz. (AP Photo/Rick Scuteri)
Seattle Seahawks quarterback Russell Wilson (3) surveys the field before the play during a game against the Arizona Cardinals, Sunday, Sec. 21, 2014, in Glendale, Ariz. (AP Photo/Gene Lower)
Seattle Seahawks' Paul Richardson bows after scoring a touchdown against the Arizona Cardinals in the second half of an NFL football game, Saturday, Dec. 24, 2016, in Seattle. (AP Photo/Ted S. Warren)
Seattle Seahawks wide receiver Doug Baldwin carries the ball after catching a pass against the Arizona Cardinals in the first half of an NFL football game, Saturday, Dec. 24, 2016, in Seattle. (AP Photo/John Froschauer)
Seattle Seahawks outside linebacker K.J. Wright (50) during an NFL football game against the Arizona Cardinals, Saturday, Dec. 24, 2016, in Seattle. The Cardinals defeated the Seahawks, 34-31. (Ryan Kang via AP)
Seattle Seahawks quarterback Russell Wilson (3) huddles up his team during the second half of an NFL football game against the Arizona Cardinals, Thursday, Nov. 9, 2017, in Glendale, Ariz. (AP Photo/Ross D. Franklin)
Arizona Cardinals quarterback Drew Stanton (5) throws against the Seattle Seahawks during the second half of an NFL football game, Thursday, Nov. 9, 2017, in Glendale, Ariz. (AP Photo/Ross D. Franklin)
Seattle Seahawks' Tyler Lockett (16) flips his way into the end zone on a 29-yard touchdown reception against the Arizona Cardinals during the first half of an NFL football game, Sunday, Dec. 30, 2018, in Seattle. (AP Photo/John Froschauer)
Seattle Seahawks' kicker Sebastian Janikowski reacts to kicking a field goal against the Arizona Cardinals during the second half of an NFL football game, Sunday, Dec. 30, 2018, in Seattle. The Seahawks won 27-24. (AP Photo/Ted S. Warren)
FILE - In this Sept. 30, 2018, file photo, Seattle Seahawks linebacker Bobby Wagner (54) gestures at the line of scrimmage during an NFL football game against the Arizona Cardinals in Glendale, Ariz. Seattle (6-5) has won two straight and has a direct path to an NFC playoff berth in a season no one really expected them to be in the conversation at the beginning of December. (AP Photo/Rick Scuteri, File)
Seattle Seahawks quarterback Russell Wilson (3) celebrates with defensive tackle Shamar Stephen (98) after an NFL football game against the Arizona Cardinals, Sunday, Sept. 30, 2018, in Glendale, Ariz. The Seahawks won 20-17. (AP Photo/Rick Scuteri)
Seahawks defensive end Jadeveon Clowney crosses into the end zone as 12s at State Farm Stadium rejoice. Clowney's 'pick-six' gave the Seahawks an 10-0 lead.
Seattle Seahawks quarterback Russell Wilson (3), right, and Arizona Cardinals quarterback Kyler Murray (1) meet after an NFL football game, Sunday, Sept. 29, 2019, in Glendale, Ariz. The Seahawks won 27-10. (AP Photo/Ross D. Franklin)
