The Seahawks came to Arizona with a perfect record in no small part due to their ability to win some crazy games, but this time they couldn't close it out, falling in overtime despite leading the entire game before the Cardinals tied it at the end of regulation.
Here are six rapid reactions to Seattle's 37-34 loss that dropped their record to 5-1:
1. This time, the Seahawks couldn't come out on top in a wild finish.
Whether it was a goal-line stop against New England or a comeback touchdown drive against Minnesota, the Seahawks have made a habit of winning close games with some late-game drama. On Sunday night, however, the Seahawks weren't able to finish the way they wanted, with the Cardinals overcoming a 10-point deficit in the final minutes, then winning in overtime after both teams squandered opportunities earlier in the overtime period.
The Seahawks started overtime with the ball, but a pair of sacks, Arizona's first two of the night, ended that possession. The Seahawks then had another chance after Zane Gonzalez missed a 41-yard attempt, but Russell Wilson was intercepted on the ensuing possession, giving the Cardinals and Gonzalez another shot, and this time he didn't miss.
This was the Seahawks' first loss when leading by four or more points, postseason included, since the start of the 2012 season. Prior to this game they had been 59-0 in such games.
2. Tyler Lockett was spectacular.
The DK Metcalf hype has been justified this season, but lest anyone forget about the Seahawks' other starting wide receiver, Tyler Lockett turned in a monster performance, catching 15 passes for 200 yards and three touchdowns.
Lockett started his day with a spectacular 1-handed grab for a 34-yard gain despite great coverage from Patrick Peterson, and he and Russell Wilson combined for one of the best plays of the game, a 47-yard touchdown late in the first half that combined a beautiful Wilson deep ball with another great catch in traffic.
Lockett's reception total tied a single-game franchise record held by Steve Largent, and his 200 receiving yards was a career best, while his three touchdowns matched a career high.
3. DK Metcalf had the hustle play of the year.
Despite a monster game and those spectacular catches, Lockett might not have made the best play of the game. That's because DK Metcalf made one of the most impressive plays of his career without touching the ball.
When Wilson lofted a pass toward the end zone, Cardinals safety Budda Baker broke on the ball and intercepted it just in front of the goal line, and the former Husky and Bellevue High standout appeared to be on his way to a 98-yard touchdown.
Metcalf, however, had other ideas, and took off sprinting, using all of his 4.33-second 40-yard dash speed to eventually catch Baker at the 8-yard line.
Had the Cardinals turned that short field into a touchdown, Metcalf's hustle would have been a nice footnote in the game, but it instead ended becoming a huge moment because the defense got a stop in the red zone, including on fourth down when the Cardinals chose to go for it instead of kicking a field goal. The Seahawks answered with a 97-yard touchdown drive, meaning what could have been a 14-13 Cardinals lead instead became a 20-7 Seahawks lead.
4. It was a mixed bag for the offense.
On one hand, the Seahawks offense was spectacular for much of the game, putting up 34 points, 572 yards and 33 first downs. But on the other hand, a team and a quarterback that are usually so good at taking care of the ball had three costly turnovers, including an interception in overtime that led to the Cardinals' winning field goal.
The Seahawks had 377 yards and 19 first downs in the first half alone, averaging 10.5 per play before halftime, and Michael Dickson didn't punt in the first half, and only punted three times in the game.
Wilson had three interceptions for the first time since 2017, but he also put up some monster numbers, throwing for 388 yards and three touchdowns, giving him 22 this season, tied with Peyton Manning in 2013 for the most in a quarterback's first six games.
Wilson also put together his best rushing performance in years, rushing for 84 yards on six carries, his most rushing yards since he had 92 against the Rams in Week 10 of the 2018 season.
Wilson was particularly impressive in the first half, throwing for 277 yards and rushing for 64, making him the first player since Michael Vick in 2010 to have 250-plus passing and 55-plus rushing in a half.
5. The defense is still looking for answers.
After giving up some huge numbers in the first three weeks, the Seahawks appeared to take some positive steps in their next two games, particularly when it came to reducing big plays. Against a talented Cardinals offense, however, Seattle's defense struggled, allowing 519 yards and 31 first downs.
The Seahawks defense did have a big fourth-down stop and two more takeaways, but unlike past games, they couldn't get the big stop at the end that they needed.
6. There were some costly injuries.
The Seahawks came into the game mostly healthy coming off of their bye, but saw two key players leave the game due to injury and not return.
Running back Chris Carson got off to a great start, averaging 6.8 yards per carry, but left in the first half with a foot injury. Cornerback Shaquill Griffin, meanwhile, suffered a concussion that took him out of the game.
The Seahawks did get a strong performance out of Carlos Hyde in relief of Carson, with Hyde rushing for 68 yards and a score on 15 carries.
The best photos from Week 7's Seahawks-Cardinals game at State Farm Stadium. Fueled by Nesquik.