| 5/5/2008 | Released DT Kelly Talavou and WR Travis Brown. Signed DT Kevin Brown and WR Joel Filani. |
| 5/2/2008 | Released DT Jonathan Lewis. Signed T Floyd Womack. |
| 4/29/2008 | Released LS Tim Lindsey. Signed DT Larry Tripplett and LB Wesly Mallard. Claimed QB Dalton Bell off waivers from Carolina. |
| 4/27/2008 | Drafted DT Red Bryant in the fourth round, FB Owen Schmitt in the fifth round, LS Tyler Schmitt in the sixth round, RB Justin Forsett and K Brandon Coutu in the seventh round of the NFL Draft. Signed free agents: S Jamar Adams, CB Donovan Alexander, WR Travis Brown, WR Michael Bumpus, LB Matt Castelo, G Dustin Dickinson, CB DeMichael Dizer, LB David Hawthorne, S Kelin Johnson, T William Robinson, WR Anthony Russo, S Eric Wicks. |
| 4/26/2008 | Drafted DE Lawrence Jackson in the first round and TE John Carlson in the second round. |
| 4/22/2008 | Released RB Shaun Alexander. |
| 4/7/2008 | Signed P Reggie Hodges and CB Omare Lowe. |
| 3/27/2008 | Signed K Olindo Mare |
| 3/26/2008 | Re-signed CB Marcus Trufant. |
| 3/25/2008 | Signed DE Chris Cooper and LB D.D. Lewis |
| 3/21/2008 | Signed LB Lofa Tatupu to contract extension |
| 3/11/2008 | Named Kasey Dunn running backs coach. |
| 3/10/2008 | Signed RB Julius Jones. |
| 3/5/2008 | Signed RB T.J. Duckett. |
| 3/4/2008 | Signed TE Jeb Putzier. Named Mike DeBord Offensive Assistant. |
| 2/29/2008 | Released T Tom Ashworth. |
| 2/14/2008 | Named Bill Lazor Quarterbacks Coach. Signed G Mike Wahle. |
| 1/25/2008 | Named Mike Solari offensive line coach |
| 1/15/2008 | Signed TE Zac Alcorn, C Nick Jones, DT Jonathan Lewis, LS Tim Lindsey and C Chris White |
| 1/9/2008 | Signed G Pat Murray |
| 1/7/2008 | Signed FB Dan Curran |
| 1/1/2008 | Placed DE Baraka Atkins on injured reserve. Signed WR Logan Payne from practice squad to actice roster. Signed DT Kelly Talavou to the practice squad. |