Click on the link in the results column for a complete game recap.
| Game Date | Start Time | Opponent | Results | TV |
| Sunday, September 10, 2006 | 10:00 am PT | at Detroit | | FOX |
| Sunday, September 17, 2006 | 1:05 pm | Arizona | | FOX |
| Sunday, September 24, 2006 | 1:00 pm PT | New York | | FOX |
| Sunday, October 01, 2006 | 5:15 pm PT | at Chicago | | NBC |
| Sunday, October 15, 2006 | 10:00 am PT | at St Louis | | FOX |
| Sunday, October 22, 2006 | 1:00 pm PT | Minnesota | | FOX |
| Sunday, October 29, 2006 | 10:00 am PT | at Kansas City | | FOX |
| Monday, November 06, 2006 | 5:30 pm PT | Oakland | | ESPN & KSTW |
| Sunday, November 12, 2006 | 1:00 pm PT | St Louis | | FOX |
| Sunday, November 19, 2006 | 1:05 pm PT | at San Francisco | | FOX |
| Monday, November 27, 2006 | 5:30 pm PT | Green Bay | | ESPN & KSTW |
| Sunday, December 03, 2006 | 5:15 pm | at Denver | | NBC |
| Sunday, December 10, 2006 | 1:15 pm | at Arizona | | FOX |
| Thursday, December 14, 2006 | 5:00 pm PT | San Francisco | | NFL Network & KCPQ TV |
| Sunday, December 24, 2006 | 1:00 pm PT | San Diego | | CBS |
| Sunday, December 31, 2006 | 10:00 am PT | at Tampa Bay | | FOX |